Efficacy and safety of transradial approach in primary PCI for STEMI

To determine the efficacy and safety of transradial approach in primary percutanous intervention in acute ST segment elevation myocardial infarction. Descriptive study Emergency reporting [ER] department of Armed Forces Institute of Cardiology National Institute of Heart Diseases [AFIC/NIHD] from Dec 2011 to Dec 2013 Retrospective data of 354 patients had been collected through records. All the patients presented with acute myocardial infarction to emergency reporting [ER] department of Armed Forces Institute of Cardiology National Institute of Heart Diseases were included in the study. All the patients underwent primary coronary intervention through transradial route. All patients received IIB IIIA inhibitors bolus and infusion. The primary end points were procedure success and local access site hematoma and secondary end points were major bleeding requiring blood transfusion and door to balloon time. The mean age of the patient was 64 +/- 18 years, there were 251 [70.9%] males and female were 103 [29.1%]. Radial access site cannulation time was 194 +/- 22 sec and door to balloon time was 78 +/- 14 min. Procedural success was 349 [98.6%]. Forearm hematoma was noted in 4 [1.12%]. No major bleeding requiring transfusion was noted. Primary percutanous intervention [PPCI] via transradial [TRI] route in acute STEMI patients can be achieved with high success and low complications in our population. The clinical outcome is matching with local and international data

Role of aspiration thrombectomy in primary PCI for STEMI - myth or reality?

The objective of the study was to determine the outcome of thrombus aspiration in Primary coronary intervention [PCI] for ST elevation myocardial infarction [STEMI]. Case Series The study was carried out in Armed Forces Institute of Cardiology - National Institute of Heart Diseases [AFIC-NIHD] over a period of twelve months from January 2013 to December 2013. Data of 30 patients who underwent aspiration thrombectomy during primary PCI for STEMI by the transradial approach was collected. Inclusion criteria were chest pain suggestive of myocardial ischemia lasting longer than 30 min accompanied by ST- segment elevation or new left bundle branch block on the ECG within 12 h of symptom onset. Patients with previous CABG, cardiogenic shock or requiring TPM placement were excluded from this study. A 6F sheath was placed inside the radial artery, and cardiac catheterization was performed. Angiographic and electrocardiographic signs of myocardial reperfusion were assessed. Study endpoints included TIMI III flow and ST-segment resolution at the end of the procedure. Mean age of the patients was 52 years [range 37-77 yrs] and 63% [n= 19] were males and 37% [n=11] were females. The right radial artery was used in 90% of cases. Thrombus aspiration catheter used was 6 F Thrombuster II [70%] and Hunter [30%].There was significant improvement in markers of myocardial reperfusion with achievement of ST-segment resolution and TIMI 3 flow in 28 patients [93%]. No case of vascular complications such as major access site bleeding, vascular perforation, radial artery occlusion, forearm ischemia, compartment syndrome or MACE was observed. Thrombus aspiration [TA] is applicable in the majority of patients undergoing primary PCI for myocardial infarction with ST-segment elevation, and it improves early markers of myocardial reperfusion

cross sectional study to assess the association between serum testosterone levels and BMI in the adult age group

OBJECTIVE: The objective of this study was to assess the association between serum testosterone levels and Body mass index [BMI] in the adult age group

STUDY DESIGN: It was a randomized cross sectional study

PLACE AND DURATION: The study was carried out at the Physiology Department of Islamic International Medical College, Rawalpindi from March 2010 to March 11

METHODS: The sample size was 56 male medical students [aged 18-25 years]. Serum total testosterone

levels were analyzed by Enzyme Linked Immunofluorescent Assay technique. Height and weight of all the students were measured using calibrated scales. Body Mass Index [BMI = Weight in kg/ Height in square meters] was calculated for each student. The positive and negative control samples were used with each batch to make sure the quality of results

RESULTS: The serum total testosterone levels decrease with the increase in BMI in the male adults aged 18-25 years. The mean serum testosterone levels of the adult males having mean BMI of 21.52 +/-2.01 were 6.92+/-2.06 [ng/ml] [p=0.000]. Those having mean BMI of 27.03+/-1.30 the serum testosterone levels were 6.72+/- 2.04 [ng/ml] [p=0.001]. In case of 35.14 +/-2.31 BMI, the levels were 6.37+/-0.19 [ng/ml] [p=0.039]

CONCLUSION: In the adult age group serum total testosterone levels were significantly negatively related to BMI